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The results suggested that supplemental carnitine intake to an individuals regular diet may significantly increase TMAO productivity in individuals with low TMAO productivity, regardless of omnivorous or vegetarian dietary habits (Fig

Drug Interactions: The concomitant use of XIGDUO XR with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation (e.g., cationic drugs) [see Drug Interactions (7)]

doi:10.1038/cmi.2010.31

Saruta F, Yamada N, Yamamoto K