The team found demyelination significantly decreased compared to the control
Specific Populations No clinically significant differences in the pharmacokinetics of selinexor were observed based on age (18 to 94 years old), sex, body weight (36 to 168 kg), ethnicity, mild to severe renal impairment (CLCR: 15 to 89 mL/min, estimated by the Cockcroft-Gault equation), and disease type (hematological, solid tumor)
To reduce the risk of misdiagnosis and overtreatment, the clinical expert consulted by CADTH suggested that treatment decisions be made by a panel of clinical experts, at least when the diagnosis of SPIGFD is uncertain
Step 2: Calculate Required Bacteriostatic Water Standard reconstitution uses 2 mL of bacteriostatic water per 5 mg vial, resulting in a concentration of 2.5 mg/mL (2,500 mcg/mL)