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Data were tested for normality using DAgostino & Pearson or ShapiroWilk tests, and equal variances were analysed using the Levene test, meeting the assumptions of the statistical tests used

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The SGLT2i rely on adequate glomerular filtration for their glycaemic benefit and are not as effective at glycaemic control in patients with CKD

"What we show in the study is an enzymatic method -- using a tiny molecular machine to modify or hyper modify peptides in extremely controlled ways -- enabling what we believe will be next generation peptide therapeutics." Eastman and Bandarian co-founded Sethera last year to bring their discoveries toward real-world applications, supported by funding from the National Institutes of Health