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every 6 months if symptomatic Oral B12 dose for repletion / 1,000 mcg/day cyanocobalamin is standard Key trial for retatrutide weight data / Phase 2 (NCT04881760, N=338), 24-week results published NEJM 2023 Neuropathy overlap risk / both B12 deficiency and GLP-1 class effects can cause GI symptoms that mask deficiency signs Regulatory status / retatrutide is not FDA-approved