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Nagy 3 , Svetlana Radaeva 6 and Gyongyi Szabo 1 , (1)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (2)University of Massachusetts Memorial Health Care, (3)Cleveland Clinic Foundation, (4)University of Louisville, Louisville, KY, (5)University of Texas Southwestern Medical Center, (6)National Institutes of Health, Bethesda, MD Background: Extracellular vesicle (EVs) cargo consists of RNA and protein molecules from the cells of origin reflecting the pathophysiological state specific to a disease and thereby, are emerging as potential biomarkers

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species adapted to prolonged frosts can also be found in areas of present-day Siberia [1]