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In summary, both direct design relying on mechanistic knowledge and available structural data from the oxytocinase subfamily of M1 aminopeptidases as well as iterative manipulations of the parent peptide Ang IV, involving insertion of unnatural amino acids as -amino acids, macrocyclizations and various structural simplifications have provided highly potent selective Ang IV peptidemimetics inhibiting IRAP

At the end of the three-month study, both groups had a significant reduction in Leeds assessment of neuropathic symptoms and signs (LANSS) and Douleur Neuropathique (DN4) scores, but there was no significant difference between groups [39,40]