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Compared to the non-depleted JFG group, the ABX + JFG group showed significantly diminished improvements in paw swelling, synovial pathology scores, and inflammatory cytokine reduction ( Strongest Supportable Conclusion: JFG efficacy has a clear microbiota dependence (providing a necessity signal) ( Limitations: No FMT or metabolite rescue/blocking was performed, making it difficult to advance from necessity to transferability and key mediator localization

found that IBD did not affect weight loss outcomes in obese patients and that anti-TNF- therapy did not reduce the likelihood of achieving 5% total weight loss (TWL) (66% vs

A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis