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Avoid the combination in Child-Pugh class B or C patients

In particular, Bcl-2 and Bcl-xL inhibit apoptosis by maintaining mitochondrial membrane integrity whereas Bax and Bak facilitate apoptosis by initiating the loss of outer mitochondrial integrity [21]

As 2 agonists lack the GABAergic activity to prevent and treat DT or seizures, they can only be used as adjunctive therapy to reduce autonomic hyperactivity that cannot be controlled by BZD alone.3, 80, 86 Several studies demonstrated a BZDsparing effect with significant reduction in BZD requirement.87, 88, 89 8.3.4

Hence, keeping it healthy is necessary for all the possible reasons