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Overlapping side effects Both berberine and semaglutide can cause gastrointestinal symptoms like: Bloating Constipation Gas Nausea Taking them together may amplify these effects

Most people who get diarrhea notice it within the first few weeks after starting treatment or after increasing their dose

A majority of people with cardiovascular disease do not have diabetes, adds Ania Jastreboff, MD, PhD, a Yale Medicine endocrinologist, who is an expert in obesity medicine and director of the Yale Obesity Research Center (Y-Weight)

Both studies showed a significant improvement with semaglutide for heart failure symptoms, physical limitations, weight loss, and six-minute walk distance compared to placebo