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Starting a GLP-1 to manage type 2 diabetes was associated with a higher chance of developing NAION within a year, based on a study using historical data of over 520,000 patients

Female response patterns and body composition changes Women achieve slightly higher percentage weight loss than men on average, though absolute pound reduction often appears lower due to smaller starting weights

Many commercial plans explicitly exclude weight management medications from their formulary

More recent evidence indicates that sustained GIP receptor agonism in the presence of GLP-1 activation enhances insulin sensitivity and may preferentially reduce visceral adipose tissue