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Funding This work was supported by the National Key R&D Program of China Scientific and Technological Innovation of Blue Granary (2018YFD0901504), the National Natural Science Foundation of China (31672630), the earmarked fund for CARS-50, Shandong Province Key Research and Development Program (2022LZGC004, 2021LZGC004), the Central Public-interest Scientific Institution Basal Research Fund (2020TD27)

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Further research is needed to address these key issues and to improve our understanding of the role of ferroptosis in male reproductive dysfunction, which may provide new insights on the treatment and prevention of testicular diseases