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Collectively, these findings are consistent with the development of relative GLP-1 resistance acquired in the context of aging or HFD feeding

Keywords: NAC, amino, glutathione, detox

Though IV and oral NAC loading doses were similar (140-150 mg/kg), the oral NAC regimen provided an additional 70 mg/kg every 4 hours for 17 doses, while the IV NAC regimen provided an additional 12.5 mg/kg/h for 4 hours, followed by 6.25 mg/kg/hr for the next 16 hours

Also, since lithium increases both CaMKK2 activity and protein abundance, it is possible that CaMKK2 may be involved in mediating the acute as well as longer-term effects of lithium such as preventing episode recurrence [176]