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EClinicalMedicine 57:101865

Start with gentle movement: Walking, stretching, or light yoga Time activity: Exercise when your energy naturally peaks Build gradually: Start with 5-10 minutes and increase slowly Consider strength training: Even brief sessions help maintain muscle mass during weight loss Avoid high-intensity exercise during periods of extreme fatigue Hydration Dehydration can worsen fatigue, and Wegovy may affect your fluid and electrolyte balance

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During physical activity, elevated IL-6 levels can slow gastric motility, contributing to enhanced postprandial satiety and improved glycemic control