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Side-Effect Tolerability and Who Should Consider Each Option Both medications cause gastrointestinal side effectsprimarily nausea, vomiting, constipation, and appetite suppression

TRT does not directly cause weight loss

Impaired fusion leads to increased mutation rates and genome loss, resulting in deficiencies in oxidative phosphorylation (OXPHOS) and significantly elevated reactive ROS (52), causing insufficient energy uptake and death of dopaminergic neurons

But the gap between those results, the side effect profiles, the costs, and the long-term sustainability of each approach has grown so wide that choosing the wrong one for your situation could mean years of frustration