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It also helps maintain balance between the body and the environment

A more precise definition of target engagement and dose-response relationships will be important to maximize benefit while minimizing potential risks associated with NRF2 overactivation ( The limited and inconsistent clinical efficacy of antioxidant strategies in MS likely reflects, at least in part, pharmacological constraints that are not captured by preclinical efficacy alone ( Nevertheless, the therapeutic implications of antioxidant strategies in MS should be interpreted cautiously

Stuhlmiller TJ, Miller SM, Zawistowski JS, Nakamura K, Beltran AS, Duncan JS, et al

Additionally, certain medications and genetic predispositions can increase susceptibility to developing hyperpigmentation, making it a multifaceted concern requiring targeted treatment approaches