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Crit Care Med 48:e173e191 Acknowledgements Not applicable Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

Plays a role in protein metabolism and cellular health

Dysregulated mTORC1 and TFEB signaling exacerbate these autophagic defects, prompting research into the use of autophagy modulators as potential therapeutic strategies [144, 146]