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For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]

M.AdamD.AgostinisP.et al (2018)

Journal of Clinical Pharmacy and Therapeutics, 46 (5), 1184-1191

This highlights a critical gap in clinical practice, emphasizing the need for hepatologists and gastroenterologists to be more proactive in identifying smoking as a risk factor for liver disease progression and in implementing strategies to promote smoking cessation among their patients