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A clinical study in Thailand evaluated this combination in 50 patients with mild to moderate acne after an initial intensive treatment phase (0.1% adapalene and benzoyl peroxide 2.5% for eight weeks)

have demonstrated that liver injury mediated by Kupffer cells can promote the proliferation and carcinogenic transformation of bile duct cells by inducing the generation of ROS and the paracrine effect of TNF, thereby activating the JNK signaling pathway