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Retatrutide vs semaglutide comparisons highlight the progression toward more potent multi-agonist approaches

Combination approaches that couple GSH-triggered release with ferroptosis induction, immunotherapy, radiotherapy, or metabolic modulation represent promising strategies to overcome resistance Fig

Disease states of GH excess (e.g., acromegaly) and GH deficiency (e.g., congenital isolated GH deficiency) are characterized by increased and decreased GH, IGF-I and insulin levels, respectively, where the GH/IGF-I relationship is reflected by a primary association

Shafabakhsh R, Mobini M, Raygan F, Aghadavod E, Ostadmohammadi V, Amirani E, et al