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IRP can bind to the iron response element (IRES) in mRNA encoding key iron regulatory proteins, including DMT1, ferritin heavy chain (FTH), TfR1, and ferritin, thereby stabilizing iron absorption, utilization, storage, and output (18)

This assumption is supported by the finding that only the overexpression of GCL, and not of GS, results in increased GSH levels ( The second pathway of GSH synthesis is that related to the recycling of cysteine

10.1038/s41586-019-1707-0 48 DuY.BagnjukK.LawsonM

Kupffer cells (KCs), which are the largest population of resident macrophages in the liver, are the first innate immune cells and protect the liver from infections