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Description

A metabolite of valproic acid, thought to be propionic acid, has the ability to increase ammonia levels by inhibiting a step in the hepatic urea cycle, which may lead to valproic acid-induced hyperammonemic encephalopathy

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Lancet 2017;Ahead of Print

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Prior exposure to piperine shielded cultured hippocampal neurons from the detrimental effects of heightened glutamatergic activity, preventing a decline in cell viability

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All are approved for use in adult populations, with no set upper age limit

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