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These findings indicate that LAC may serve as a precision medicine biomarker with LAC levels being used together with clinical characteristics (e.g., depression severity, age of onset and history of childhood trauma) to aid the diagnosis of biological based depression subtypes

Methods: We searched PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and EMBASE, including RCTs comparing EVT to MM in AIS patients published since 2014

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