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A 2026 review describes GLP-1 signalling influencing keratinocyte function, immune cell activity and wound healing, and modulating pathways including cAMP/PKA, AMPK, PI3K/Akt and NF-kappaB as well as the IL-23/Th17/IL-17 axis

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Consequently, selenium deficiency lowers deiodinase activity, which impairs T4-to-T3 conversion, leads to aberrant thyroid hormone levels, and disrupts normal physiological functions