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For DSIP Mechanism still unclear Inconsistent results Benefits often small Many studies show limited clinical significance For Sermorelin & GH-Axis Peptides GH manipulation can disrupt hormonal balance Not approved for sleep treatment Side effects can include fluid retention, numbness, cortisol disruption Long-term effects of off-label use unknown Sleep outcomes not strongly supported in trials Legal Reality None of these peptides are FDA-approved for insomnia or any sleep disorder

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10.3389/fendo.2019.00480 Front