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Based on these findings, we propose that the multiple cell death pathways induced by Erastin in EMS create a tightly regulated positive feedback network centered around free iron and ROS

L-carnitine is a naturally occurring molecule that transports the fatty acids from the inside of the cell to the "powerhouses of the cell", the mitochondria, where fat burning (energy production) takes place

doi:10.1086/596476

Therefore, HO-1, as a key factor in the inflammatory response, is expected to provide effective strategies for the prevention and treatment of diabetic complications and can provide novel ideas and drug targets for the prevention and treatment of clinical diseases