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In addition to weight loss, as compared with old unspecific serotonin agonists, lorcaserin had beneficial effects on surrogate markers of cardiovascular and diabetes risk, including decreases in blood pressure values, heart rate, total and LDL cholesterol, fasting glucose, insulin levels, C-reactive protein, and fibrinogen
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The half-life of retatrutide is approximately six days, which is why weekly dosing works pharmacologically the drug stays active in your system through the week, maintaining receptor activation without requiring daily shots