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Alcohol disrupts sleep architecture, particularly REM sleep, and poor sleep is associated with increased hunger hormone signaling and reduced satiety hormone signaling

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[] Additionally, mutations in processing enzymes like prohormone convertase 1/3 (encoded by PCSK1 gene) impair proteolytic release of POMC-derived -MSH, causing obesity with glucose dysregulation

Bupropion increases dopamine and norepinephrine to control emotional eating and reduce hunger