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In humans, serum levels of ALLO are normally stable during the first 2 years of life (212)

Their shear-thinning properties permit administration through standard syringe needles, and their biodegradability ensures gradual clearance from the body without local inflammation [46]

Therefore, the use of PBPK modelling to extrapolate the initial doses for pediatric clinical trials has been steadily increasing in the last few years, and recognized by authorities (Heimbach et al., 2019