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In emergency treatment of acquired methemoglobinemia (typically using IV MB), the dose is weight-based, usually 1-2 mg/kg intravenously, which for an average adult (70 kg) is on the order of 70-140 mg administered once and can be repeated once if needed

Methionine-R-sulfoxide reductase B1 (formerly selenoprotein R) The methionine sulfoxide reduction system is involved in the protection against oxidative stress and is especially critical for the regeneration of proteins damaged by ROS

That cycle of peaks and troughs makes adherence harder and the overall effect weaker

[(1) One patent Issued (3/20/12) Lipidomic approaches to determine drug response phenotypes in cardiovascular disease Patent # 8137977, expires 12/10/27