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Additionally, Paneth cells from ClpP IEC mice contained fewer granules positive for the antimicrobial peptide lysozyme (Lyz + ) ( Figure 5E,F ), despite overall Paneth cell abundance remaining unchanged (data not shown)

In addition, labile iron pools can catalyze lipid radical propagation through Fenton-type reactions, further amplifying membrane lipid peroxidation [71, 72]

Tirzepatide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes

This distinction matters because abnormal glucose, liver enzymes, kidney markers, lipids, or nutritional markers may predate semaglutide use