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Management of GI AEs Tailored dietary strategies, combined with structured dose-escalation protocols and patient education on meal timing, portion sizes, and food choices, can mitigate GI symptoms and support long-term therapeutic success

Data Extraction Extracted variables included study design, peptide agent and formulation, dosing regimen and route of administration when reported, musculoskeletal indication, comparator group, outcome measures, efficacy findings, and adverse events

This dose level is where split dosing starts to show clear advantages for researchers with GI sensitivity

By supporting appetite regulation and digestion, many patients experience steady progress over time rather than rapid, short-term changes that are difficult to maintain long term