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B12 administration may cause rapid optic atrophy in these patients Have polycythemia vera

Ethics declarations Ethics approval and consent to participate All procedures performed in studies involving human participants were in accordance with the ethical standards of Royan Institute and the 1964 Helsinki declaration and its later amendments or comparable ethical standards (Ethics approval number: IR.ACECR.ROYAN.REC.1397.156)

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The most common adverse events are transient gastrointestinal disturbances (nausea, diarrhea, constipation, vomiting) occurring predominantly during dose escalation