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If CrAT can generate acetyl-CoA for histone acetylation, we anticipated that the supplementation of acetylcarnitine to the culture media should boost histone acetylation and proliferation in lipid-depleted DKO cells, and this was indeed the case (Figure 6B, C)
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PC=Placebo An RCT of nondiabetic patients (N = 1961)1: After 68 weeks, mean weight loss was 15% (15 kg) versus 2% (3 kg) PC
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