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Unlike smaller, lipophilic nootropics that absorb well through buccal mucosa, dihexa's molecular weight and hydrophilic amide groups limit transmucosal absorption

Patients with mild, recently developed deficiency typically respond more rapidly than those who have been deficient for months or years

less water does the opposite

While you could technically take a supplement containing NAD+ as the primary ingredient, research suggests that its bioavailability isnt nearly as good as two of its precursors: nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).46 Besides NAD+, NR is also a precursor to NMN.47 And since NMN is closer to becoming NAD+ than NR is, some people feel that its the better option, but either one should be effective.48 If youre interested in these supplements, it could be worth trying one of each type (NR or NMN) to see which works better for you