Once reuptaken into the cell, GABA is metabolized by GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH) into succinate, which is then involved in the tricarboxylic acid (TCA) cycle
After release of TML by lysosomal protein degradation, this compound is hydroxylated by TMLD, after which the resulting HTML is cleaved by a specific aldolase, which uses pyridoxal 5-phosphate (PLP) as a cofactor, into TMABA and glycine Substrate and Intermediate Compounds Trimethyllysine (TML) TML is the starting substrate for carnitine biosynthesis, derived from the methylation of lysine residues in proteins
Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Silman AJ, Barrett EM, et al
Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas