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34 The AHA guidelines endorse GLP-1 RAs, including semaglutide and liraglutide, because these medications have shown significant benefits in reducing major adverse cardiovascular events (MACE) and heart failure exacerbations, as demonstrated in the LEADER and SUSTAIN-6 trials (Table 3)

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They work most efficiently on small, resistant fat pockets that do not respond to diet or exercise, such as under the chin, around the abdomen, thighs, arms, and bra line

Os sintomas geralmente persistem por pelo menos seis meses e podem incluir dores musculares, dor de cabea, distrbios gastrointestinais e sensibilidade aumentada a estmulos sensoriais