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Studies using the GABA analog in Fmr1 knockout mice demonstrated corrections in hyperactivity and modulation of altered sensory-motor gating, measured as increased prepulse inhibition following acute treatment, by enhancing the activity of extrasynaptic GABA receptors, thereby improving anxiety, aggression, and repetitive behavioral abnormalities in FXS mice (71)
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Impaired potentiation of theta oscillations during a visual cortical plasticity paradigm in individuals with schizophrenia
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