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As the improvement in redox status of the brain has been observed in these studies, it seems that riboflavin exerts its antioxidant properties mainly through other antioxidant enzymes (which have not been assessed) or through mechanisms independent of the glutathione cycle or antioxidant enzymes, such as deactivation of reactive oxygen species (ROS) through the conversion of the reduced form of riboflavin to its oxidised form (Reference Ashoori and Saedisomeolia12)

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