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But for individuals who have plateaued on semaglutide or who want the most aggressive pharmacological approach to weight loss, tirzepatide offers a meaningful step up in efficacy

The inflammatory milieu subsequently drives hepatic stellate cell activation and transdifferentiation into myofibroblasts, leading to excessive extracellular matrix deposition and progressive fibrosis, which represents the primary determinant of long-term liver-related outcomes [17]

4,7 In this regard, this addition ensures a more comprehensive discussion aligned with current expert consensus on risk mitigation strategies

[10] [11] Small clinical trials of liraglutide in HFrEF (FIGHT and LIVE) have shown heart rate increases and potential safety signals, suggesting caution in this population