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Each system was superimposed on the GLP-1R coordinates retrieved from the OPM database 62 in order to correctly orient the receptor before it was inserted 63 in a rectangular 125 116 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine (POPC) bilayer (previously built by using the VMD Membrane Builder plugin 1.1, Membrane Plugin, Version 1.1

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In a phase 2 trial, people with T2D and overweight/obesity achieved greater mean WL with cagrisema 2.4 mg compared to cagrilintide 2.4 mg or semaglutide 2.4 mg alone after 32 weeks of treatment (15.6% WL vs