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In microglia, FMN suppresses KMT2B expression, thereby downregulating TNFR1/NF-B activity and curbing the release of pro-inflammatory cytokines like IL-1 and TNF- (10, 66)

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Indeed, inflammation begins in adipose tissue and gradually spreads to adjacent sites such as skeletal muscle and liver until a systemic, low-grade inflammatory state, also known as metabolic inflammation, develops and fails to resolve (156)