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Metabolic profiling of PPAR / mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

Industry analysts estimate that small-molecule production costs could be 10 to 100 times lower than peptide biologics, a differential that could fundamentally alter the health economics of GLP-1 therapy and expand access to hundreds of millions of patients worldwide who currently cannot afford or access injectable treatments

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These project to adjacent A2 cells in the NTS and are involved in the decreased food intake associated with anorexic agents such as lithium chloride and cholecystokinin (65, 66)