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Description

The results highlight nitrosative redox chemistry as a potentially physiologically relevant pathway for dsNNTTR formation and support a model in which controlled thiol modification, rather than generalized oxidative stress, may contribute to pathological TTR crosslinking in vivo

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The methylation cycle requires three B vitamins as cofactors: Folate (B9) : Required for the remethylation of homocysteine to methionine via the enzyme MTHFR (methylenetetrahydrofolate reductase)

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