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The distinction matters and for many people dealing with gastrointestinal conditions, the correct answer is to use them together

These polymorphisms are likely to contribute to the difference between individuals in responses to xenobiotics and clearance of oxidative stress products and have been associated with various pathologies such as cancer, and cardiovascular or respiratory diseases [60]

Both NAC and ALC have demonstrated neuroprotective effects by modulating glutamate levels (Baker et al., 2002