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Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders

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5.4 Considerations for intranasal delivery IN delivery provides a non-invasive and accessible dosing route for medication administration, but it also has several concerns that necessitate careful consideration

Others are approved for type 2 diabetes and may lead to weight loss as a secondary effect