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FIGURE 3 To further confirm the hypothesis of a regulation of CBS activity by the Akt/GSK3 and/or NF-B pathways, we assessed the impact of inhibitors of these pathway (9-methylstreptimidone, 8-hydroxy verrucarin A, chrysomycin and daunorubicin) on the mRNA levels of CBS , CSE and NAD(P)H quinone oxidoreductase 1 ( NQO1 ), three genes known to be regulated by these pathways (Wang et al., 2014

The former enrolled 469 non diabetic obese individuals aged 47.951.7 years with moderate-to-severe OSA (mean BMI 38.739.1 kg/m 2 ) and showed a 17.719.6% BW reduction with the highest tolerated dose of tirzepatide vs