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The defining study, Neelakantan and colleagues in Biochemical Pharmacology (2018), reported that a potent methylquinolinium NNMT inhibitor reduced body weight, white-fat mass, adipocyte size and plasma cholesterol in diet-induced obese mice, without changing food intake or causing overt adverse findings [1]

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Primary iron overload is caused by genetic disorders that dysregulate the absorption of dietary iron, whereas secondary iron overload develops due to repeated blood transfusions, drug-induced toxicity, or excess consumption of iron [64]