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A fraction of TMAO present in food (e.g., marine fish) is absorbed unchanged into the portal circulation, and the rest is metabolized to TMA in the large intestine by the action of bacterial TMAO reductase (TorA) (Krger et al., 2017

Pandi-Perumal SR, Trakht I, Srinivasan V, et al

Handling of dropouts or missing data Handling of dropouts or missing data For the efficacy endpoints, the last observation carried forward method was used for missing data imputation