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Another characteristic of PD is oxidative DNA damage, which triggers PARP activation, leading to the depletion of NAD + levels 40,279,282,283,284

A split schedule can be used when the goal is to distribute signaling opportunities rather than concentrate all exposure into a single administration window

Similarly, in DLB, neuroinflammation due to the lack of SCFAs is mitigated in the substantia nigra but not in the cortex by secondary bile acids generated by the increased abundance of Ruminococcus torques and Collinsella 80

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