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As the majority of patients with type 2 diabetes are overweight or obese this offers a potential advantage over older, established therapies, and DPP-4 inhibitors are being used in clinical practice as second-line therapy in addition to metformin in overweight and obese patients who fail to reach glycemic targets with metformin monotherapy

Fertility can return before a woman is aware her cycle has regularized another reason reliable contraception is important early in treatment

Novo Nordisk will work closely with healthcare providers and regulators to continually assess the level of need along with available supply to help ensure that patients who start treatment can remain on treatment

They may include: They may include: Nausea Vomiting Diarrhea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Abdominal pain Decreased appetite Indigestion Redness at injection site Redness at injection site Most symptoms improve over time